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The hormone gastrin and the vagus nerve trigger the release of both pepsinogen and HCl from the stomach lining when food is ingested. Hydrochloric acid creates an acidic environment, which allows pepsinogen to unfold and cleave itself in an autocatalytic fashion, thereby generating pepsin (the active form). Pepsin cleaves the 44 amino acids ...
Thyroid function tests (TFTs) is a collective term for blood tests used to check the function of the thyroid. [1] TFTs may be requested if a patient is thought to suffer from hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid), or to monitor the effectiveness of either thyroid-suppression or hormone replacement therapy.
Chief cells are part of fundic gland polyps (here shown in high magnification). [11]In gastric tissue, a loss of parietal cells due to chronic inflammation has been shown to affect chief cell differentiation and can induce chief cells to transdifferentiate back into neck cells and can lead to the formation of mucus cell metaplasia known as spasmolytic polypeptide expressing metaplasia (SPEM ...
pepsinogen secretion Parietal cell: hydrochloric acid secretion Pancreatic acinar cell pancreas bicarbonate and digestive enzyme secretion Paneth cell: small intestine: lysozyme secretion Type II pneumocyte: lungs: surfactant secretion Club cell: Type I pneumocyte: formation of the Blood-Gas Barrier Barrier cell Gall bladder epithelial cell ...
Parietal cells produce potent hydrochloric acid, which damages cells. Gastric chief cells produce pepsinogen, which is activated by the acid to form pepsin. Pepsin is a protease that can digest and damage stomach cells. To prevent these disastrous effects, mucus and bicarbonate ions (HCO 3 −) are secreted by the foveolar cells.
The oxyntic gland contains the parietal cells that produce hydrochloric acid and intrinsic factor, and chief cells that produce pepsinogen and gastric lipase. The pyloric gland is found in the pyloric region, the remaining 20 per cent of the stomach. The pyloric glands are mainly in the pyloric antrum. The pyloric gland secretes gastrin from ...
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