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The magic bullet is a scientific concept developed by the German Nobel laureate Paul Ehrlich in 1907. [1] While working at the Institute of Experimental Therapy (Institut für experimentelle Therapie), Ehrlich formed an idea that it could be possible to kill specific microbes (such as bacteria), which cause diseases in the body, without harming the body itself.
Magic bullet (medicine), the pharmacological ideal of a drug able to selectively target a disease without other effects on the body, originally defined by Paul Ehrlich as a drug for antibacterial therapy
Ehrlich's team began their search for such a "magic bullet" among chemical derivatives of the dangerously toxic drug atoxyl. Arsphenamine was used to treat the disease syphilis because it is toxic to the bacterium Treponema pallidum , a spirochete that causes syphilis.
Ehrlich introduced the concept of a magic bullet. He also made a decisive contribution to the development of an antiserum to combat diphtheria and conceived a method for standardising therapeutic serums. [1] In 1908, he received the Nobel Prize in Physiology or Medicine for his contributions to immunology. [2]
At the Congress for Internal Medicine at Wiesbaden in April 1910, Ehrlich and Hata shared their successful clinical results, which showed that arsphenamine treated syphilis in humans. [7] The drug was marketed under the name Salvarsan and gained international acclaim as the "arsenic that saves" and as the first man-made antibiotic . [ 7 ]
Ex-Secret Service agent Paul Landis has broken his silence six decades on from Kennedy assassination to challenge the official findings
The development of magnetic nanoparticle drug delivery started with Paul Ehrlich's concept of a "magic bullet". [1] The concept was built during the 1970s with the application of the anticancer drug doxorubicin in animal models. The first successful clinical trial of the process occurred in 1996. [2]
A class action lawsuit filed last year in US District Court in Minnesota argued that UnitedHealthcare uses AI “in place of real medical professionals to wrongfully deny elderly patients care ...