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Telomerase is a reverse transcriptase enzyme that carries its own RNA molecule (e.g., with the sequence 3′-CCCAAUCCC-5′ in Trypanosoma brucei) [3] which is used as a template when it elongates telomeres. Telomerase is active in gametes and most cancer cells, but is normally absent in most somatic cells.
He studies telomerase, the enzyme that copies the telomeric sequences and lengthens them. [8] The active site protein subunits of telomerase comprise a new class of reverse transcriptases, enzymes previously thought to be restricted to viruses and transposable elements. Telomerase is activated in 90% of human
Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. [5] [6] Telomerases are part of a distinct subgroup of RNA-dependent polymerases.
21745 Ensembl ENSG00000129566 ENSMUSG00000006281 UniProt Q99973 P97499 RefSeq (mRNA) NM_007110 NM_001319035 NM_009351 RefSeq (protein) NP_001305964 NP_009041 NP_033377 Location (UCSC) Chr 14: 20.37 – 20.41 Mb Chr 14: 51.06 – 51.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene. Function This ...
In most multicellular eukaryotic organisms, telomerase is active only in germ cells, some types of stem cells such as embryonic stem cells, and certain white blood cells. [9] Telomerase can be reactivated and telomeres restored to the embryonic state by somatic cell nuclear transfer. [18]
Telomerase RNA component, also known as TR, TER or TERC, is an ncRNA found in eukaryotes that is a component of telomerase, the enzyme used to extend telomeres. [ 3 ] [ 4 ] TERC serves as a template for telomere replication ( reverse transcription ) by telomerase.
Elizabeth Helen Blackburn (born 26 November 1948) is an Australian-American Nobel laureate who is the former president of the Salk Institute for Biological Studies. [2] In 1984, Blackburn co-discovered telomerase, the enzyme that replenishes the telomere, with Carol W. Greider.
After six months of additional research, Greider and Blackburn concluded that it was the enzyme responsible for telomere addition. They published their findings in the journal Cell in December 1985. [10] The enzyme, originally called "telomere terminal transferase," is now known as telomerase.