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Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
Tetracyclines have a broad spectrum of antibiotic action. Originally, they possessed some level of bacteriostatic activity against almost all medically relevant aerobic and anaerobic bacterial genera, both Gram-positive and Gram-negative , with a few exceptions, such as Pseudomonas aeruginosa and Proteus spp. , which display intrinsic resistance.
Tetracyclines(Bs) Demeclocycline: Declomycin: Syphilis, chlamydial infections, Lyme disease, mycoplasmal infections, acne rickettsial infections, malaria [note 1] Gastrointestinal upset; Sensitivity to sunlight; Potential toxicity to mother and fetus during pregnancy; Enamel hypoplasia (staining of teeth; potentially permanent) Transient ...
For example, chloramphenicol and tetracyclines are antagonists to penicillins. However, this can vary depending on the species of bacteria. [74] In general, combinations of a bacteriostatic antibiotic and bactericidal antibiotic are antagonistic. [71] [72]
Oxytetracycline, like other tetracyclines, is used to treat many infections, both common and rare.Its better absorption profile makes it preferable to tetracycline for moderately severe acne at a dosage of 250–500 mg four times a day for usually six to eight weeks at a time, but alternatives should be sought if no improvement occurs by three months.
Production of antibiotics is a naturally occurring event, that thanks to advances in science can now be replicated and improved upon in laboratory settings. Due to the discovery of penicillin by Alexander Fleming, and the efforts of Florey and Chain in 1938, large-scale, pharmaceutical production of antibiotics has been made possible.
Synonyms; Kitasatospora psammotica (Virgilio and Hengeller 1960) Labeda et al. 2017; Streptomyces aureofaciens Duggar 1948 (Approved Lists 1980); Streptomyces avellaneus Baldacci and Grein 1966 (Approved Lists 1980)
Tetracyclics are cyclic chemical compounds that contain four fused rings of atoms, for example, Tröger's base. Some tricyclic compounds having three fused and one tethered ring (connected to main nucleus by a single bond) can also classified as tetracyclic, for example, ciclazindol. [1] Tetracyclic compounds have various pharmaceutical uses ...