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Paracetamol poisoning was first described in the 1960s. [6] Rates of poisoning vary significantly between regions of the world. [8] In the United States more than 100,000 cases occur a year. [1] In the United Kingdom it is the medication responsible for the greatest number of overdoses. [7] Young children are most commonly affected. [1]
Paracetamol's bioavailability is dose-dependent: it increases from 63% for 500 mg dose to 89% for 1000 mg dose. [6] Its plasma terminal elimination half-life is 1.9–2.5 hours, [ 6 ] and volume of distribution is roughly 50 L. [ 134 ] Protein binding is negligible, except under the conditions of overdose, when it may reach 15–21%. [ 6 ]
Appearance. An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [ 1 ] Tables of this general type are also available for NSAIDs ...
Antipyretic. An antipyretic (/ ˌæntipaɪˈrɛtɪk /, from anti- 'against' and pyretic 'feverish') is a substance that reduces fever. [1] Antipyretics cause the hypothalamus to override a prostaglandin -induced increase in temperature. [citation needed] The body then works to lower the temperature, which results in a reduction in fever.
Timeline of US drug overdose death rates by race and ethnicity. [4] Rate per 100,000 population. The word "overdose" implies that there is a common safe dosage and usage for the drug; therefore, the term is commonly applied only to drugs, not poisons, even though many poisons as well are harmless at a low enough dosage.
NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen). [1] It is normally produced only in small amounts, and then almost immediately detoxified in the liver. However, under some conditions in which NAPQI is not effectively ...