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Although prostacyclin is considered an independent mediator, it is called PGI 2 (prostaglandin I 2) in eicosanoid nomenclature, and is a member of the prostanoids (together with the prostaglandins and thromboxane). PGI 2, derived primarily from COX-2 in humans, is the major arachidonate metabolite released from the vascular endothelium. This is ...
The prostacyclin receptor, also termed the prostaglandin I 2 receptor or just IP, is a receptor belonging to the prostaglandin (PG) group of receptors. IP binds to and mediates the biological actions of prostacyclin (also termed prostaglandin I 2 , PGI 2 , or when used as a drug, epoprostenol).
Similarly, prostacyclin (PGI 2) synthase (PGIS) converts PGH 2 into PGI 2. A thromboxane synthase has also been identified. Prostaglandin-F synthase (PGFS) catalyzes the formation of 9α,11β-PGF 2α,β from PGD 2 and PGF 2α from PGH 2 in the presence of NADPH.
All other prostanoids originate from PGH (as PGH 1, PGH 2, or PGH 3). The image at right shows how PGH 2 (derived from Arachidonic acid) is converted: By PGE synthetase into PGE2 (which in turn is converted into PGF2) By PGD synthetase into PGD2; By Prostacyclin synthase into prostacyclin (PGI2) By Thromboxane synthase into thromboxanes TXA
19223 Ensembl ENSG00000124212 n/a UniProt Q16647 O35074 RefSeq (mRNA) NM_000961 NM_008968 RefSeq (protein) NP_000952 NP_032994 Location (UCSC) Chr 20: 49.5 – 49.57 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Prostaglandin-I synthase (EC 5.3.99.4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in ...
Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, (i.e. PGD2), PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2. [1]
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The PGE 2, PGE 1, and PGD 2 products formed in the pathways just cited can undergo a spontaneous dehydration reaction to form PGA 2, PGA 1, and PGJ 2, respectively; PGJ 2 may then undergo a spontaneous isomerization followed by a dehydration reaction to form in series Δ12-PGJ 2 and 15-deoxy-Δ12,14-PGJ 2. [39] PGH 2 has a 5-carbon ring bridged ...
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