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The Vroman effect, named after Leo Vroman, describes the process of competitive protein adsorption to a surface by blood serum proteins. The highest mobility proteins generally arrive first and are later replaced by less mobile proteins that have a higher affinity for the surface.
Proteins and other molecules are constantly in competition with one another over binding sites on a surface. The Vroman Effect, developed by Leo Vroman, postulates that small and abundant molecules will be the first to coat a surface. However, over time, molecules with higher affinity for that particular surface will replace them.
In "soft" protein coronas, it is common to observe an exchange of proteins at the surface; larger proteins with lower affinities will often aggregate to the surface of the nanoparticle first, and over time, smaller proteins with higher affinities will replace them, "hardening" the corona, known as the Vroman effect. [3]
Dr. Vroman's list of accomplishments include winning nearly every Dutch literary award for poetry; having illustrations and drawings that hang in Dutch museums; a scientific output that includes 69 research papers, many of them published in Elsevier journals; and a discovery named after him: the Vroman Effect. He has also published 60 books, 40 ...
The Vroman effect can describe the time-dependent behavior of this protein adsorption. [9] Surface-adsorbed proteins regulate inflammatory cell interaction and adhesion. [9] The deposited proteins allow inflammatory cells to attach via integrins. [9] The biomaterial surface can also recruit and activate complement proteins. [9]
The Zeeman effect, named after the Dutch physicist Pieter Zeeman, is the effect of splitting a spectral line into several components in the presence of a static magnetic field. It is analogous to the Stark effect , the splitting of a spectral line into several components in the presence of an electric field .
The Vroman effect is influenced by protein concentration relative to the surface area and diffusion coefficients. [ 6 ] [ 9 ] Overall, this affects the protein surface binding affinity. For example, Ehrenburg et al. have shown that fibrinogen presence rapidly declines with polystyrene nanoparticles containing functional groups, such as COOH and ...
Vroman effect; W. White blood cell This page was last edited on 26 October 2024, at 12:06 (UTC). Text is available under the Creative Commons Attribution ...