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3569 16193 Ensembl ENSG00000136244 ENSMUSG00000025746 UniProt P05231 P08505 RefSeq (mRNA) NM_000600 NM_001318095 NM_001371096 NM_031168 NM_001314054 RefSeq (protein) NP_000591 NP_001305024 NP_001358025 NP_001300983 NP_112445 Location (UCSC) Chr 7: 22.73 – 22.73 Mb Chr 5: 30.22 – 30.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 6 (IL-6) is an interleukin that acts ...
The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [6] IL6R subunit is also shared by many other cytokines.
Hyper-IL-6 is a designer cytokine, which was generated by the German biochemist Stefan Rose-John. [1] Hyper-IL-6 is a fusion protein of the four-helical cytokine Interleukin-6 and the soluble Interleukin-6 receptor which are covalently linked by a flexible peptide linker. [1] Interleukin-6 on target cells binds to a membrane bound Interleukin-6 ...
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Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It is a 15.5–16 kDa protein [ 5 ] that regulates the activities of white blood cells (leukocytes, often lymphocytes ) that are responsible for immunity.
In fact, eccentric exercise may result in a delayed peak and a much slower decrease of plasma IL-6 during recovery. [23] Anti-IL-6 therapies should therefore take into consideration the (beneficial) anti-inflammatory effects of myokines generally, including the now-established multiple benefits of muscle-derived Interleukin 6. [23]
Glycoprotein 130 (also known as gp130, IL6ST, IL6R-beta or CD130) is a transmembrane protein which is the founding member of the class of tall cytokine receptors.It forms one subunit of the type I cytokine receptor within the IL-6 receptor family.