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Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. [4] Present in animals since early stages of evolution, in humans it plays roles in behavior that include social bonding, love, reproduction, childbirth, and the period after childbirth.
During pregnancy, the syncytiotrophoblast cells of the placenta produce a polypeptide hormone, human placental lactogen (hPL), also known as human chorionic somatomammotropin (hCS). [ 17 ] in six weeks of gestation , production of hPL in maternal plasma is detected, then the concentration of hPL keeps increasing until week 30 of pregnancy. [ 17 ]
High levels of prolactin during pregnancy and breastfeeding also increase insulin resistance, increase growth factor levels (IGF-1) and modify lipid metabolism in preparation for breastfeeding. During lactation, prolactin is the main factor maintaining tight junctions of the ductal epithelium and regulating milk production through osmotic balance.
A woman's breasts change during pregnancy to prepare them for breastfeeding a baby. Normal changes include: Tenderness of the nipple or breast; An increase in breast size over the course of the pregnancy; Changes in the color or size of the nipples and areola; More pronounced appearance of Montgomery's tubercles (bumps on the areola)
Many nonhuman studies can be used as both potential models for humans and to show the phylogenetic conservation of some endocrine signals. [1] Estrogen and progesterone released by ovaries during pregnancy make oxytocin receptors more sensitive in female rats [8] and is associated with the onset of maternal behaviors in other species as well.
The breasts change during pregnancy to prepare for lactation, and more changes occur immediately after the birth. Progesterone is the hormone that influences the growth of breast tissue before the birth. Afterwards, the endocrine system shifts from producing hormones that prevent lactation to ones that trigger milk production. [3]
Human chorionic gonadotropin (hCG), progesterone, 17β-estradiol, endorphins and gonadotropin-releasing hormone (GnRH) synthesis are rapidly upregulated by the developing embryo following fertilization of the ovum. [1] [2] [3] During early embryonic development, paracrine/juxtacrine signaling of hCG induces blastulation and neurulation.
It is possible for a mother to continue breastfeeding an older sibling while also breastfeeding a new baby; this is called tandem nursing. During the late stages of pregnancy, the milk changes to colostrum. While some children continue to breastfeed even with this change, others may wean. Most mothers can produce enough milk for tandem nursing ...