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Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of pregnancy, jaundice of pregnancy, and prurigo gravidarum, [1] is a medical condition in which cholestasis occurs during pregnancy. [2] It typically presents with itching and can lead to complications for both mother and fetus. [2]
Intrahepatic cholestasis of pregnancy (ICP) is an acute cause of cholestasis that manifests most commonly in the third trimester of pregnancy. [15] It affects 0.5–1.5% of pregnancies in Europe and the US and up to 28% in women of Mapuche ethnicity in Chile. [61]
Acute fatty liver of pregnancy is a rare condition and occurs in approximately one in 7,000 to one in 15,000 pregnancies. [3] [19] The mortality from acute fatty liver of pregnancy has been reduced significantly to 18%, and is now related primarily to complications, particularly DIC (Disseminated Intravascular Coagulation) and infections.
How ATP8B1 mutation leads to cholestasis is not yet well understood. [citation needed] PFIC-2 is caused by a variety of mutations in ABCB11, the gene that codes for the bile salt export pump, or BSEP. Retention of bile salts within hepatocytes, which are the only cell type to express BSEP, causes hepatocellular damage and cholestasis. [citation ...
Cholestatic pruritus is the sensation of itch due to nearly any liver disease, but the most commonly associated entities are primary biliary cholangitis, primary sclerosing cholangitis, obstructive choledocholithiasis, carcinoma of the bile duct, cholestasis (also see drug-induced pruritus), and chronic hepatitis C viral infection and other forms of viral hepatitis.
This three-piece set comes with everything one needs for holiday cooking: 12.5-inch dish holds that holds 4 quarts; a 10-inch dish that holds 2.5 quarts; and a 7.5-inch dish that holds 1.1 quart.
Generally, diseases outlined within the ICD-10 codes K70-K77 within Chapter XI: Diseases of the digestive system should be included in this category. Subcategories This category has the following 4 subcategories, out of 4 total.
(The Center Square) – While overdose deaths increased by roughly 15% across Spokane County last year, data from last month already surpassed that of January 2024 and suggests it could make 2025 ...