Ads
related to: treatment herpes simplex keratitis
Search results
Results From The WOW.Com Content Network
Herpetic simplex keratitis is a form of keratitis caused by recurrent herpes simplex virus (HSV) infection in the cornea. [ 1 ] It begins with infection of epithelial cells on the surface of the eye and retrograde infection of nerves serving the cornea. [ 2 ]
Idoxuridine is mainly used topically to treat herpes simplex keratitis. [3] Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. [4] Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster. [3]
ZVZ keratitis may cause clouding of the cornea, with 50% of cases involving inflammatory infiltrates in the stromal layer of the cornea, corneal scarring is a possible complication of VZV keratitis. [3] Vaccination with the zoster vaccine is highly effective in preventing shingles, as well as herpes zoster ophthalmicus and herpes zoster ...
Ganciclovir is also available in slow-release formulations for insertion into the vitreous humour of the eye, as treatment for CMV retinitis (associated with HIV infection). A topical ophthalmic gel preparation of ganciclovir was recently [when?] approved for the treatment of acute herpes simplex keratitis. [citation needed]
Vidarabine is an antiviral, active against herpes viruses, poxviruses, rhabdoviruses, hepadnaviruses and some RNA tumour viruses. A 3% ophthalmic ointment Vira-A is used in the treatment of acute keratoconjunctivitis and recurrent superficial keratitis caused by HSV-1 and HSV-2. [29]
A Cochrane Systematic Review examined the effectiveness of multiple antiviral drugs in the treatment of herpes simplex virus epithelial keratitis. Brivudine was found to be significantly more effective than idoxuridine in increasing the number of successfully healed eyes of participants. [10]