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Unlike the Wolff–Chaikoff effect, the Plummer effect does not prevent the thyroid from taking up radioactive iodine, e.g. in the case of nuclear emergencies.Therefore, "plummering" with high-dose iodine is only effective in a short time window after the release of radionuclides. [9]
Administering the radioactive isotope causes the thyroid to take in the lethal iodine and quickly radiation destroys it. [12] Typically overproduction of thyroxine using radio-iodine is blocked with one dose. The drawback to this treatment is the thyroid gland is completely destroyed and patients often develop hypothyroidism. Some do so only a ...
Only the Wolff–Chaikoff effect is helpful to prevent the thyroid from uptaking radioactive iodine in the case of nuclear emergencies. Therefore, "plummering" with high-dose iodine is only effective in a short time window after the release of radionuclides. [15] Wrong timing of iodine use may even increase the risk by triggering the Plummer ...
During the production of the thyroid hormones, hydrogen peroxide is produced in large quantities, and therefore high iodine in the absence of selenium can destroy the thyroid gland (often described as a sore throat feeling); the peroxides are neutralized through the production of glutathione from selenium. In turn, an excess of selenium ...
A deficiency of iodine leads to decreased production of T 3 and T 4 and a concomitant enlargement of the thyroid tissue in an attempt to obtain more iodine, causing the disease goitre. The major form of thyroid hormone in the blood is tetraiodothyronine (T 4), which has a longer life than triiodothyronine (T 3).
People who have Graves disease, toxic multinodular goiter, or various types of thyroid adenoma are also at risk of the Jod-Basedow effect when receiving iodine, because the thyroid will then not respond to the negative feedback from increased thyroid hormones. The source of iodine may be from the diet, administration of iodinated contrast for ...
Thyroid peroxidase, also called thyroperoxidase (TPO), thyroid specific peroxidase or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid. Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T 4 ) or ...
The beta particles emitted by the radioisotope destroys the associated thyroid tissue with little damage to surrounding tissues (more than 2.0 mm from the tissues absorbing the iodine). Due to similar destruction, 131 I is the iodine radioisotope used in other water-soluble iodine-labeled radiopharmaceuticals (such as MIBG ) used ...