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Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). [3] ALA, which is made in animals normally, is essential for aerobic metabolism. It is also available as a dietary supplement or pharmaceutical drug in some countries.
Central alpha agonists lower blood pressure by stimulating alpha-receptors in the brain which open peripheral arteries easing blood flow. These alpha 2 receptors are known as autoreceptors which provide negative feedback in neurotransmission (in this case, the vasoconstriction effects of adrenaline). Central alpha agonists, such as clonidine ...
Onset of effects is around 5 hours and they last about a day. [1] Common side effects include sleepiness. [1] More severe side effects include red blood cell breakdown, liver problems, and allergic reactions. [1] Methyldopa is in the alpha-2 adrenergic receptor agonist family of medication.
Activation of the TRPA-1 receptor by lipoic acid or podocarpic acid has been shown to reduce the levels of AGES by enhancing the detoxification of methylglyoxal, a major precursor of several AGEs. [38] Studies in rats and mice have found that natural phenols such as resveratrol and curcumin can prevent the negative effects of the AGEs. [46] [47]
Chelation therapy is a medical procedure that involves the administration of chelating agents to remove heavy metals from the body. [1] Chelation therapy has a long history of use in clinical toxicology [2] and remains in use for some very specific medical treatments, although it is administered under very careful medical supervision due to various inherent risks, including the mobilization of ...
Alpha lipoic acid (ALA) is an antioxidant that is made naturally by human cells. [50] It can also be administered in capsules or can be found in foods such as red meat, organ meats, and yeast. [ 50 ] Like other antioxidants, it functions by ridding the body of harmful free radicals that can cause damage to tissues and organs. [ 50 ]