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In general, proton pump inhibitors are well tolerated, and the incidence of short-term adverse effects is relatively low. The range and occurrence of adverse effects are similar for all of the PPIs, though they have been reported more frequently with omeprazole. This may be due to its longer availability and, hence, clinical experience.
They are used to treat certain gastrointestinal symptoms, including abdominal discomfort, bloating, constipation, heart burn, nausea, and vomiting; and certain gastrointestinal disorders, including irritable bowel syndrome, gastritis, [2] gastroparesis, and functional dyspepsia.
The prebiotics in asparagus can help stave off constipation and the bloating that can accompany it. “[Asparagus] contains inulin, a prebiotic, leading to better bowel regularity,” says Yoon.
Unlike the colon (or large bowel), which is rich with bacteria, the small bowel usually has fewer than 100,000 organisms per millilitre. [1] Patients with bacterial overgrowth typically develop symptoms which may include nausea, bloating, vomiting, diarrhea, malnutrition, weight loss, and malabsorption [2] by various mechanisms.
Like other PPIs, rabeprazole is absorbed into the blood stream at the site of the proximal small bowel. [55] Rabeprazole's mechanism of action involves crossing from the blood stream into the parietal cells of the stomach, which are the cells that are responsible for secreting hydrochloric acid (HCl). [11] At this point, rabeprazole is inactive ...
When antacids do not provide enough relief, medications such as H 2 blockers and proton-pump inhibitors that help reduce the amount of acid are often prescribed. [29] [30] Cytoprotective agents are designed to help protect the tissues that line the stomach and small intestine. [31] They include the medications sucralfate and misoprostol.