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When a tablet press is used for dry granulation, the powders may not possess enough natural flow to feed the product uniformly into the die cavity, resulting in varying density. The roller compactor (granulator-compactor) uses an auger-feed system that will consistently deliver powder uniformly between two pressure rollers. The powders are ...
A tablet press in operation An old rotary tablet press. A tablet press is a mechanical device that compresses powder into tablets of uniform size and weight. A tablet press can be used to manufacture tablets of a wide variety of materials, including pharmaceuticals, nutraceuticals, cleaning products, industrial pellets and cosmetics.
Pharmaceutical manufacturing is the process of industrial-scale synthesis of pharmaceutical drugs as part of the pharmaceutical industry. The process of drug manufacturing can be broken down into a series of unit operations , such as milling , granulation , coating , tablet pressing , and others.
The pharmaceutical sector, in particular, has emerged as a significant revenue generator, as these machines aid in creating precise granules for drug formulations. The rise in demand for dry and wet granulators in drug manufacturing, coupled with a surge in contract manufacturing services, is driving innovation in this segment. Moreover, the ...
The compression is done either by a single-punch machine (also called stamping press, achieves an output of approximately 200 tablets per minute, making it ideal for manufacturing small batches of tablets) or by a multi-station machine (rotary press). The tablet press is a high-speed mechanical device.
Fluid undergoes shear when one area of fluid travels with a different velocity relative to an adjacent area. A high-shear mixer uses a rotating impeller or high-speed rotor, or a series of such impellers or inline rotors, usually powered by an electric motor, to "work" the fluid, creating flow and shear.
Industrial shredder. This shredder is set up in line with a granulator, in order to reduce the size of the processed material more. An industrial shredder is a machine used to break down materials for various applications such as recycling, volume reduction, and product destruction. Industrial shredders come in many different sizes and design ...
More specifically, the ISPE's guide The Good Automated Manufacturing Practice (GAMP) Guide for Validation of Automated Systems in Pharmaceutical Manufacture describes a set of principles and procedures that help ensure that pharmaceutical products have the required quality. One of the core principles of GAMP is that quality cannot be tested ...