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High doses of caffeine intake during pregnancy may increase the risk of miscarriage [48] and some major negative pregnancy outcomes, such as stillbirth or low birth weight. [ 49 ] [ 50 ] A 2020 review called into question the safe levels proposed by the European Food Safety Authority, the American Congress of Obstetricians and Gynecologists ...
Pregnant women are often confused about caffeine consumption. A new meta-analysis published in the journal BMJ Evidence-Based Medicine finds a correlation between caffeine consumption and adverse ...
The metabolism of caffeine is reduced in pregnancy, especially in the third trimester, and the half-life of caffeine during pregnancy can be increased up to 15 hours (as compared to 2.5 to 4.5 hours in non-pregnant adults). [79] Evidence regarding the effects of caffeine on pregnancy and for breastfeeding are inconclusive. [26]
Loperamide has limited data on the impact it has on pregnancy, but there is an association with cardiovascular malformation in the first trimester. [14] [12] Atropine/diphenoxylate currently has insufficient evidence of teratogenicity in humans, but trials with animals showed evidence of teratogenic effects. [14]
Contraindicated in pregnancy: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
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The health effects of coffee include various possible health benefits and health risks. [1]A 2017 umbrella review of meta-analyses found that drinking coffee is generally safe within usual levels of intake and is more likely to improve health outcomes than to cause harm at doses of 3 or 4 cups of coffee daily.
Additional energy is required during pregnancy due to the expansion of maternal tissues and stored to support fetal development. In the first trimester (blastogenesis and early embryonic stages), the mother experiences a minimal weight gain (approximately 0.5-2 kilograms), while the embryo weighs only 6 grams.