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White matter is composed of bundles, which connect various grey matter areas (the locations of nerve cell bodies) of the brain to each other, and carry nerve impulses between neurons. Myelin acts as an insulator, which allows electrical signals to jump , rather than coursing through the axon, increasing the speed of transmission of all nerve ...
These perisomatic (around the cell body) and basal dendrites project into all cortical layers, but most of their horizontal branches/arbors populate layers V and VI, some reaching down into the white matter. [5] According to one study, Betz cells represent about 10% of the total pyramidal cell population in layer Vb of the human primary motor ...
A deficiency in GALC thus causes a buildup of these fatty acids, leading to an incursion by cells called "globoid macrophages" that destroy oligodendrocytes, thereby inhibiting any further myelin formation. [20] Given the presence of globoid macrophages clustered near white matter, Krabbe disease often is called globoid cell leukodystrophy.
Oligodendrocytes are a type of glial cell, non-neuronal cells in the central nervous system.They arise during development from oligodendrocyte precursor cells (OPCs), [8] which can be identified by their expression of a number of antigens, including the ganglioside GD3, [9] [10] [11] the NG2 chondroitin sulfate proteoglycan, and the platelet-derived growth factor-alpha receptor subunit (PDGF ...
White matter, which is mostly composed of myelinated axons (hence its white color) and glial cells, is generally not considered to be a part of the neuropil. [citation needed] Neuropil (pl. neuropils) comes from the Greek: neuro, meaning "tendon, sinew; nerve" and pilos, meaning "felt". [2] The term's origin can be traced back to the late 19th ...
Pathways through cerebral white matter can be charted by histological dissection and staining, by degeneration methods, and by axonal tracing. Axonal tracing methods form the primary basis for the systematic charting of long-distance pathways into extensive, species -specific anatomical connection matrices between gray matter regions.
Oligodendrocyte progenitor cells (OPCs), also known as oligodendrocyte precursor cells, NG2-glia, O2A cells, or polydendrocytes, are a subtype of glia in the central nervous system named for their essential role as precursors to oligodendrocytes and myelin. [1] They are typically identified in the human by co-expression of PDGFRA and CSPG4.
Another cell population that is becoming increasingly implicated in MS is microglia. These cells are resident to & keep watch over the CNS, responding to pathogens by shifting between pro- & anti-inflammatory states. Microglia are involved in the formation of MS lesions and be involved in other diseases that primarily affect the CNS white matter.