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DNA origami is the nanoscale folding of DNA to create arbitrary two- and three-dimensional shapes at the nanoscale. The specificity of the interactions between complementary base pairs make DNA a useful construction material, through design of its base sequences. [ 2 ]
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Thus, in nucleic acids the sequence determines the pattern of binding and thus the overall structure. [ 5 ] Nucleic acid design is the process by which, given a desired target structure or functionality, sequences are generated for nucleic acid strands which will self-assemble into that target structure.
DNA origami structures can be designed with specific attachment sites for other nanoscale components, such as nanoparticles, fluorophores, or proteins. By measuring the distances between these components on the origami structures, researchers can perform precise distance measurements at the nanoscale through atomic force microscopy (AFM) and ...
Rothemund's DNA origami contains a long strand which folding is assisted by several short strands. This method allowed forming much larger structures than formerly possible, and which are less technically demanding to design and synthesize. [7] DNA origami was the cover story of Nature on March 15, 2006. [13]
Researchers from Seoul University, Harvard and a tire company teamed up to make a shape shifting wheel after analyzing the water bomb tessellation origami pattern.
Police in Laos have detained the manager and seven staff members of a backpacker hostel in Vang Vieng following the deaths of six tourists from suspected methanol poisoning, state media reported ...
MINFLUX has been used to image DNA origami [1] [10] and the nuclear pore complex [11] and to elucidate the architecture of subcellular structures in mitochondria and photoreceptors. [ 12 ] [ 13 ] Because MINFLUX does not collect large numbers of photons emitted from target molecules, localization is faster than with conventional camera-based ...