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Vitamin B 12 deficiency, also known as cobalamin deficiency, is the medical condition in which the blood and tissue have a lower than normal level of vitamin B 12. [5] Symptoms can vary from none to severe. [1] Mild deficiency may have few or absent symptoms. [1]
Furthermore, deficiencies in vitamin B12 can result in dysmyelination. [4] [5] Demyelinating diseases are traditionally classified into two types: demyelinating myelinoclastic diseases and demyelinating leukodystrophic diseases. In the first group, a healthy and normal myelin is destroyed by toxic substances, chemicals, or autoimmune reactions.
“Vitamin B12 is an essential water-soluble vitamin that plays a critical role in helping the brain and nervous system function,” says Ashley Kitchens, RDN, of Plant Centered Nutrition. “It ...
Inflammatory demyelinating diseases (IDDs), sometimes called Idiopathic (IIDDs) due to the unknown etiology of some of them, are a heterogenous group of demyelinating diseases - conditions that cause damage to myelin, the protective sheath of nerve fibers - that occur against the background of an acute or chronic inflammatory process.
Ultimately, doctors stress that a vitamin B12 deficiency and the symptoms that come with it are reversible. “The effects of supplements are often noticed within weeks,” Sachdev says. More on ...
Other ways to get extra B12. A prescription form of vitamin B12 can be given as an injection, notes the NIH—typically for people with deficiencies who also have problems absorbing vitamin B12 as ...
The disease can also be caused by inhalation of nitrous oxide, which inactivates vitamin B12. [11] Vitamin E deficiency, which is associated with malabsorption disorders such as cystic fibrosis and Bassen-Kornzweig syndrome, [12] can cause a similar presentation due to the degeneration of the dorsal columns. [5]
There are not enough studies on whether pills are as effective in improving or eliminating symptoms as parenteral treatment. [12] Folate supplementation may affect the course and treatment of pernicious anemia if vitamin B 12 not replaced. [65] In some severe cases of anemia, a blood transfusion may be needed to resolve haematological effects. [5]