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[7] [65] There is also initial evidence that major depression and stress can alter the permeability of the blood-brain barrier, allowing substances which would normally not be able to pass through enter the brain, thereby increasing the ways peripheral inflammation can affect the brain. [65] [79]
Negative emotions at work can be formed by "work overload, lack of rewards, and social relations which appear to be the most stressful work-related factors". [17] "Cynicism is a negative effective reaction to the organization. Cynics feel contempt, distress, shame, and even disgust when they reflect upon their organizations" (Abraham, 1999).
Central nervous system (CNS) depression is a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness, possibly leading to coma or death. It is the result of inhibited or suppressed brain activity .
Depression can affect your moods, causing you to feel sad, anxious or empty. It can also affect the way you think, resulting in feelings of helplessness and a perception that your situation may ...
A 2023 Gallup survey found that self-reported rates of depression had increased by 10% between 2015 and 2023. The study also found that one in six Americans were currently in treatment for depression.
Depression may affect people's ability to work. The combination of usual clinical care and support with return to work (like working less hours or changing tasks) probably reduces sick leave by 15%, and leads to fewer depressive symptoms and improved work capacity, reducing sick leave by an annual average of 25 days per year. [162]
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