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[97] [98] At high doses, statins have anti-inflammatory effects, incite reduction of the necrotic plaque core, and improve endothelial function, leading to plaque stabilization and, sometimes, plaque regression. [98] [97] There is a similar thought process with using high-dose atorvastatin as a form of secondary thrombotic stroke recurrence ...
They act by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol. High cholesterol levels have been associated with cardiovascular disease. [8] There are various forms of statins, some of which include atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin. [9]
Low-dose aspirin therapy. Beta-blockers. Nitroglycerin. Statins and other cholesterol-lowering drugs. Calcium channel blockers. Long-acting nitrates. Endovascular surgery. Coronary artery bypass ...
The West of Scotland Coronary Prevention Study (also known as WOSCOPS) was a landmark [1] randomized controlled trial, published in 1995, that investigated the effects of pravastatin, a cholesterol-lowering drug, on primary prevention of coronary heart disease (CHD) in men with hypercholesterolemia. Conducted in the early 1990s, this study ...
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Statins, such as Lipitor, Crestor and Zocor, are widely used to protect against high levels of LDL cholesterol, one of the causes of cardiovascular disease. ... Calculates risk separately for men ...