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For treatment-resistant adolescent depression [25] or for cancer-related depression [26] amitriptyline is no better than placebo; however, the number of treated patients in both studies was small. It is sometimes used for the treatment of depression in Parkinson's disease, [27] but supporting evidence for that is lacking. [28]
Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a first-generation antidepressant. [36] Nortriptyline may also have a sleep-improving effect due to antagonism of the H 1 and 5-HT 2A receptors. [37]
Elavil (amitriptyline) – a tricyclic antidepressant used as a first-line treatment for neuropathic pain; Eurodin, Prosom – a benzodiazepine derivative with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties, commonly prescribed for short-term treatment of insomnia
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
Amitriptyline Nortriptyline (Amitriptyline's active metabolite) Perphenazine Notes SERT: 3.13: 16.5? It is this and its NET-inhibiting action is believed to give amitriptyline its antidepressant action. NET: 22.4: 4.37? See above. DAT: 5380: 3100? 5-HT 1A: 450: 294: 421: Binding for human brain receptors had to be substituted in amitriptyline ...
The TCAs are used primarily in the clinical treatment of mood disorders such as major depressive disorder (MDD), dysthymia, and treatment-resistant variants. They are also used in the treatment of a number of other medical disorders, including cyclic vomiting syndrome (CVS) and anxiety disorders such as generalized anxiety disorder (GAD), social phobia (SP) also known as social anxiety ...
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