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The absorption half-life of subdermal testosterone implants is 2.5 months. [8] The replacement interval is once every four to six months. [41] [87] A single 50 mg testosterone pellet implanted every 4 to 6 months has been found to result in testosterone levels of 70 to 90 ng/dL in women. [41]
For reference, testosterone enanthate has an elimination half-life of 4.5 days and a mean residence time of 8.5 days and requires frequent administration of approximately once per week. [21] Large fluctuations in testosterone levels result with it, with levels initially being elevated and supraphysiological. [21]
Testosterone propionate is administered in oil via intramuscular injection. [1] [2] It has a relatively short elimination half-life and mean residence time of 2 days and 4 days, respectively. [1] [2] As such, it has a short duration of action and must be administered two to three times per week. [16]
Testosterone undecanoate has a very long elimination half-life and mean residence time when given as a depot intramuscular injection. [27] [7] [8] Its elimination half-life is 20.9 days and its mean residence time is 34.9 days in tea seed oil, while its elimination half-life is 33.9 days and its mean residence time is 36.0 days in castor oil.
Testosterone is the primary male sex hormone and androgen in males. [3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.
What is the Normal Testosterone Level for a 70-Year-Old Man? 156–819 ng/dL. The researchers also broke the data down into normal levels of free testosterone and bioavailable testosterone.
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Pharmacokinetics of testosterone esters Testosterone ester Form Route T max Tooltip Time to peak levels t 1/2 Tooltip Elimination half-life MRT Tooltip Mean residence time; Testosterone undecanoate: Oil-filled capsules: Oral? 1.6 hours: 3.7 hours Testosterone propionate: Oil solution: Intramuscular injection? 0.8 days: 1.5 days Testosterone ...
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