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In molecular biology, RNA polymerase ... Supercoiling plays an important part in polymerase activity because of the unwinding and rewinding of DNA. Because regions of ...
RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. [11] It consists of RNA polymerase II, a subset of general transcription factors , and regulatory proteins known as SRB proteins.
RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, ...
RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. [ 1 ] [ 2 ] It consists of RNA polymerase II , a subset of general transcription factors , and regulatory proteins known as SRB proteins [ clarification needed ] .
RNA polymerase core enzyme binds to the bacterial general transcription (sigma) factor to form RNA polymerase holoenzyme and then binds to a promoter. [6] (RNA polymerase is called a holoenzyme when sigma subunit is attached to the core enzyme which is consist of 2 α subunits, 1 β subunit, 1 β' subunit only).
A second version of the central dogma is popular but incorrect. This is the simplistic DNA → RNA → protein pathway published by James Watson in the first edition of The Molecular Biology of the Gene (1965). Watson's version differs from Crick's because Watson describes a two-step (DNA → RNA and RNA → protein) process as the central ...
The first RNA polymerase ribozyme was reported in 1996, and was capable of synthesizing RNA polymers up to 6 nucleotides in length. [23] Mutagenesis and selection has been performed on an RNA ligase ribozyme from a large pool of random RNA sequences, [ 24 ] resulting in isolation of the improved "Round-18" polymerase ribozyme in 2001 which ...
The variable affinity of RNA polymerase for different promoter sequences is related to regions of consensus sequence upstream of the transcription start site. The more nucleotides of a promoter that agree with the consensus sequence, the stronger the affinity of the promoter for RNA Polymerase likely is. [4]