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A tophus (Latin: "stone", pl.: tophi) is a deposit of monosodium urate crystals, in people with longstanding high levels of uric acid (urate) in the blood, a condition known as hyperuricemia. Tophi are pathognomonic for the disease gout. Most people with tophi have had previous attacks of acute arthritis, eventually leading to the formation of ...
Tophi is when uric acid crystals around the joints form larger, hard deposits. It can lead to pain, soft tissue damage, and joint deformities. Folks with gout are more prone to certain other ...
Arms and hands of a 50-year-old man, showing large tophi of sodium urate affecting the elbow, knuckles, and finger joints. The crystallization of uric acid , often related to relatively high levels in the blood, is the underlying cause of gout.
Heberden's nodes are hard or bony swellings that can develop in the distal interphalangeal joints (DIP) (the joints closest to the end of the fingers and toes). [1] They are a sign of osteoarthritis and are caused by formation of osteophytes (calcific spurs) of the articular (joint) cartilage in response to repeated trauma at the joint.
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Osler's nodes result from the deposition of immune complexes. [2] The resulting inflammatory response leads to swelling, redness, and pain that characterize these lesions. ...
Janeway lesions present as red, painless macules and papules on the palms and soles. [1]They are not common and are frequently indistinguishable from Osler's nodes.Rarely, they have been reported in cases of systemic lupus erythematosis (SLE), gonococcemia (disseminated gonorrhoea), haemolytic anaemia and typhoid fever.
The hands and feet of people with ectrodactyly are often described as "claw-like" and may include only the thumb and one finger (usually either the little finger, ring finger, or a syndactyly of the two) with similar abnormalities of the feet. [7] People with oligodactyly often have full use of the remaining digits and adapt well to their ...