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A small proportion of humans show partial or apparently complete innate resistance to HIV, the virus that causes AIDS. [1] The main mechanism is a mutation of the gene encoding CCR5, which acts as a co-receptor for HIV. It is estimated that the proportion of people with some form of resistance to HIV is under 10%. [2]
HIV-1 protease or PR is a ... The reverse transcriptase converts viral RNA into DNA, ... One approach to minimizing the development of drug-resistance in HIV is to ...
The HIV-1 integrase (IN) is a key enzyme in the replication mechanism of retroviruses. [9] It is responsible for the transfer of virally encoded DNA into the host chromosome which is a necessary event in retroviral replication. [10]
The genome and proteins of HIV (human immunodeficiency virus) have been the subject of extensive research since the discovery of the virus in 1983. [1] [2] "In the search for the causative agent, it was initially believed that the virus was a form of the Human T-cell leukemia virus (HTLV), which was known at the time to affect the human immune system and cause certain leukemias.
Atazanavir showed better resistant profiles than previous HIV protease inhibitors. [4] It is unique among the other protease inhibitors as it can only be absorbed in an acidic environment. [11] Tipranavir is a nonpeptidic HIV-1 protease inhibitor [11] and reached the market in 2005. [18]
Reverse transcriptase (RT) is an enzyme that controls the replication of the genetic material of HIV and other retroviruses. [1] The enzyme has two enzymatic functions. Firstly it acts as a polymerase where it transcribes the single-stranded RNA genome into single-stranded DNA and subsequently builds a complementary strand o
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