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The software also includes reference interval estimation, [9] meta-analysis and sample size calculations. The first DOS version of MedCalc was released in April 1993 and the first version for Windows was available in November 1996.
Epi Info is used for analysis in medical research, and for data entry. Examples of its use for research include a study of eye conditions, [6] a study of healthcare infections [7] and a study of psychiatric morbidity. [8] Examples of papers that used Epi Info for data entry include a study on nutrition [9] and an epidemiological survey about ...
An example of a Kaplan–Meier plot for two conditions associated with patient survival. The Kaplan–Meier estimator, [1] [2] also known as the product limit estimator, is a non-parametric statistic used to estimate the survival function from lifetime data. In medical research, it is often used to measure the fraction of patients living for a ...
There are several software suites available to estimate relative survival rates. Regression modelling can be performed using maximum likelihood estimation methods by using Stata or R. [4] [5] For example, the R package cmprsk may be used for competing risk analyses which utilize sub-distribution or 'Fine and Gray' regression methods. [6]
In full generality, the accelerated failure time model can be specified as [2] (|) = ()where denotes the joint effect of covariates, typically = ([+ +]). (Specifying the regression coefficients with a negative sign implies that high values of the covariates increase the survival time, but this is merely a sign convention; without a negative sign, they increase the hazard.)
In early 2000, the software was developed into a client–server model architecture, and shortly afterward, the client front-end interface component was rewritten fully and replaced with a new Java front-end, which allowed deeper integration with the other tools provided by SPSS. SPSS Clementine version 7.0: The client front-end runs under Windows.
Paul Meier (July 24, 1924 – August 7, 2011) [1] was a statistician who promoted the use of randomized trials in medicine. [2] [3]Meier is known for introducing, with Edward L. Kaplan, the Kaplan–Meier estimator, [4] [5] a method for measuring how many patients survive a medical treatment from one duration to another, taking into account that the sampled population changes over time.
An early paper to use the Kaplan–Meier estimator for estimating censored costs was Quesenberry et al. (1989), [3] however this approach was found to be invalid by Lin et al. [4] unless all patients accumulated costs with a common deterministic rate function over time, they proposed an alternative estimation technique known as the Lin ...