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acute lymphoblastic leukemia [4] lymphoma [5] [6] post-splenectomy state [7] CARD11-related congenital B cell lymphocytosis (rare, also known as BENTA disease) [8] Causes of relative lymphocytosis include: age less than 2 years; acute viral infections; connective tissue diseases, [9] thyrotoxicosis, [10] Addison's disease, [11]
Some children with autoimmune lymphoproliferative disorders are heterozygous for a mutation in the gene that codes for the Fas receptor, which is located on the long arm of chromosome 10 at position 24.1, denoted 10q24.1. [3] This gene is member 6 of the TNF-receptor superfamily (TNFRSF6).
Measured by flow cytometry: Normal values <2.5% total T cells; <1% of total lymphocytes in peripheral blood; Marked elevations >5% virtually pathognomonic for ALPS; Mild elevations also found in other autoimmune diseases; Thought to be cytotoxic T lymphocytes that have lost CD8 expression; Unknown if driver of disease or epiphenomenon
Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic condition in which individuals have increased blood levels of particular subtypes of monoclonal lymphocytes (i.e. an aberrant and potentially malignant group of lymphocytes produced by a single ancestral cell). This increase must persist for at least 3 months. [1]
Epstein–Barr virus–associated lymphoproliferative diseases (also abbreviated EBV-associated lymphoproliferative diseases or EBV+ LPD) are a group of disorders in which one or more types of lymphoid cells (a type of white blood cell), i.e. B cells, T cells, NK cells, and histiocytic-dendritic cells, are infected with the Epstein–Barr virus (EBV).
These disorders are subdivided into three main classes, which are lymphoproliferative disorders, hypergammaglobulinemia, and paraproteinemia. [1] The first is cellular, and the other two are humoral (however, humoral excess can be secondary to cellular excess.)
ICD-10 coding number Diseases Database coding number Medical Subject Headings Iron-deficiency anemia: D50: 6947: Iron-deficiency anemia (or iron deficiency anaemia) is a common anemia that occurs when iron loss (often from intestinal bleeding or menses) occurs, and/or the dietary intake or absorption of iron is insufficient. In such a state ...
Epstein–Barr virus–associated lymphoproliferative diseases; F. ... Monoclonal B-cell lymphocytosis; ... This page was last edited on 2 April 2018, ...