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Lung cancer is the most diagnosed and deadliest cancer worldwide, with 2.2 million cases in 2020 resulting in 1.8 million deaths. [3] Lung cancer is rare in those younger than 40; the average age at diagnosis is 70 years, and the average age at death 72. [2] Incidence and outcomes vary widely across the world, depending on patterns of tobacco use.
In the fifty years leading up to the Wynder and Graham study, lung cancer was observed to have risen dramatically and disproportionately in comparison to other cancers. From the 1920s to 1950, the year of the study's publication, deaths from lung cancer had quadrupled so now it was the leading cancer found in men. [8]
Celsus (c.25 BC – 50 AD) translated carcinos into cancer, the Latin word for crab or crayfish. In the 2nd century AD, the Greek physician Galen used oncos (Greek for 'swelling') to describe all tumours, reserving Hippocrates' term carcinos for malignant tumours. Galen also used the suffix -oma to indicate cancerous lesions.
Non-small-cell lung cancer (NSCLC), or non-small-cell lung carcinoma, is any type of epithelial lung cancer other than small-cell lung cancer (SCLC). NSCLC accounts for about 85% of all lung cancers. [1][2][3] As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small-cell carcinoma.
The signs and symptoms of this specific type of lung cancer are similar to other forms of lung cancer, and patients most commonly complain of persistent cough and shortness of breath. Adenocarcinoma is more common in patients with a history of cigarette smoking, and is the most common form of lung cancer in younger women and Asian populations.
Small-cell carcinoma is a type of highly malignant cancer that most commonly arises within the lung, [1] although it can occasionally arise in other body sites, such as the cervix, [2] prostate, [3] and gastrointestinal tract. Compared to non-small cell carcinoma, small cell carcinoma is more aggressive, with a shorter doubling time, higher ...