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Vitamin K 2 or menaquinone (MK) (/ ˌ m ɛ n ə ˈ k w ɪ n oʊ n /) is one of three types of vitamin K, the other two being vitamin K 1 (phylloquinone) and K 3 . K 2 is both a tissue and bacterial product (derived from vitamin K 1 in both cases) and is usually found in animal products or fermented foods .
Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. [1] The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation, for "coagulation") or for controlling binding of calcium in bones and other tissues. [2]
4256 17313 Ensembl ENSG00000111341 ENSMUSG00000030218 UniProt P08493 P19788 RefSeq (mRNA) NM_001190839 NM_000900 NM_008597 RefSeq (protein) NP_000891 NP_001177768 NP_032623 Location (UCSC) Chr 12: 14.88 – 14.89 Mb Chr 6: 136.85 – 136.85 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Matrix Gla protein (MGP) is member of a family of vitamin K 2 dependent, Gla -containing proteins ...
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Menadione is converted to vitamin K 2 (specifically, MK-4) by the prenyltransferase action of vertebrate UBIAD1. [4] This reaction requires the hydroquinone (reduced) form of K 3, menadiol, produced by NQO1. [6] Menadione is also a circulating form of vitamin K, produced in small amounts (1–5%) after intestinal absorption of K 1 and K 2.
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