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2. Gonadotropin-releasing hormone antagonist - Wikipedia

   en.wikipedia.org/wiki/Gonadotropin-releasing...

   The reduction in testosterone levels that occurs during GnRH antagonist therapy subsequently reduces the size of the prostate cancer. This in turn results in a reduction in prostate-specific antigen (PSA) levels in the patient's blood and so measuring PSA levels is a way to monitor how patients with prostate cancer are responding to treatment ...

3. Androgen deprivation therapy - Wikipedia

   en.wikipedia.org/wiki/Androgen_deprivation_therapy

   Androgen deprivation therapy (ADT), also called androgen ablation therapy or androgen suppression therapy, is an antihormone therapy whose main use is in treating prostate cancer. Prostate cancer cells usually require androgen hormones, such as testosterone, to grow. ADT reduces the levels of androgen hormones, with drugs or surgery, to prevent ...

4. Antiandrogen - Wikipedia

   en.wikipedia.org/wiki/Antiandrogen

   In addition to active treatment of prostate cancer, antiandrogens are effective as prophylaxis (preventatives) in reducing the risk of ever developing prostate cancer. [32] Antiandrogens have only limitedly been assessed for this purpose, but the 5α-reductase inhibitors finasteride and dutasteride and the steroidal AR antagonist spironolactone ...

5. Hormonal therapy (oncology) - Wikipedia

   en.wikipedia.org/wiki/Hormonal_therapy_(oncology)

   The estrogen diethylstilbestrol (DES) is occasionally used to treat prostate cancer through suppression of testosterone production. It was previously used in the treatment of breast cancer, but has been replaced by more effective and less toxic agents. Estrace is an estrogen which was also formerly used for antiandrogen therapy of prostate ...

6. Management of prostate cancer - Wikipedia

   en.wikipedia.org/wiki/Management_of_prostate_cancer

   Surgical removal of the prostate, or prostatectomy, is a common treatment either for early-stage prostate cancer or for cancer that has failed to respond to radiation therapy. The most common type is radical retropubic prostatectomy , when the surgeon removes the prostate through an abdominal incision.

7. RNAi nanoparticles to target cancer - Wikipedia

   en.wikipedia.org/wiki/RNAi_nanoparticles_to...

   In prostate cancer, the androgen receptor (AR) plays a critical role in progression of the cancer. Lipid nanoparticles (LNPs) are being considered for delivering siRNA to silence AR. Lipid nanoparticles (LNPs) are being considered for delivering siRNA to silence AR.