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Mikhail Ostrogradsky, mathematician and physicist, author of divergence theorem and partial fractions in integration; Grigori Perelman, major contributor to Riemannian geometry and topology, proved Geometrization conjecture and Poincaré conjecture, won a Fields medal and the first Clay Millennium Prize Problems Award (declined both)
Careful analysis with biostatistical methods is required to separate the signal from the noise. For example, a microarray could be used to measure many thousands of genes simultaneously, determining which of them have different expression in diseased cells compared to normal cells. However, only a fraction of genes will be differentially expressed.
This is equivalent to a linear increase of at least 10 26 times in every spatial dimension—equivalent to an object 1 nanometre (10 −9 m, about half the width of a molecule of DNA) in length, expanding to one approximately 10.6 light-years (100 trillion kilometres) long in a tiny fraction of a second.
Lake Tahoe (/ ˈ t ɑː h oʊ /; Washo: Dáʔaw) is a freshwater lake in the Sierra Nevada of the Western United States, straddling the border between California and Nevada.Lying at 6,225 ft (1,897 m) above sea level, Lake Tahoe is the largest alpine lake in North America, [4] and at 122,160,280 acre⋅ft (150.7 km 3) it trails only the five Great Lakes as the largest by volume in the United ...