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Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19 [5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin [5] of the cell nucleus.
The cause of PML is a type of polyomavirus called the JC virus (JCV), after the initials of the person (John Cunningham) from whose tissue the virus was first successfully cultured. Publications indicate 39 [ 3 ] to 58% [ 4 ] of the general population are seropositive for antibodies to JCV, indicating current or previous infection with the virus.
Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]
Kelly has previously said she lost 85 pounds after gastric bypass surgery in 2020 and also lost weight after becoming a mother to her son, Sidney, in 2022. Image credits: kellyosbourne Image ...
Postoperative cognitive dysfunction (POCD) is a decline in cognitive function (especially in memory and executive functions) that may last from 1–12 months after surgery, or longer. [1] In some cases, this disorder may persist for several years after major surgery. [2] POCD is distinct from emergence delirium. Its causes are under ...
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The body responds to postoperative wounds in the same manner as it does to tissue damage acquired in other circumstances. The inflammatory response is designed to create homeostasis. This first step is called the inflammatory stage. [1] The next stage and wound healing is the infiltration of leukocytes and release of cytokines into the tissue ...
A seroma is usually caused by surgery. Seromas are particularly common after breast surgery [3] (e.g., mastectomy), [4] abdominal surgery, and reconstructive surgery. It can also be seen after neck surgery, [1] thyroid and parathyroid surgery, [5] and hernia repair. [2] The larger the surgical intervention, the more likely that seromas form.