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Midodrine is a prodrug which forms the active metabolite, desglymidodrine, which is an α 1-adrenergic receptor agonist and exerts its actions via activation of α 1-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure.
Vasopressin is a hormone that affects the kidneys and reduces urine flow. [4] Side effects may include stomach ache, vertigo, pale skin, flatulence, headache, or tremor. [3] [4] It is available as a generic medication. [5]
The most obvious cause is a kidney or systemic disorder, including amyloidosis, [2] polycystic kidney disease, [3] electrolyte imbalance, [4] [5] or some other kidney defect. [ 2 ] The major causes of acquired nephrogenic diabetes insipidus that produce clinical symptoms (e.g., polyuria) in the adult are lithium toxicity and high blood calcium .
Vasopressin is released into the brain in a circadian rhythm by neurons of the suprachiasmatic nucleus. [21] Vasopressin released from posterior pituitary is associated with nausea. [22] Recent evidence suggests that vasopressin may have analgesic effects. The analgesia effects of vasopressin were found to be dependent on both stress and sex. [23]
Urea: oral daily ingestion has shown favorable long-term results with protective effects in myelinosis and brain damage. [19] Limitations noted to be undesirable taste and is contraindicated in people with cirrhosis to avoid initiation or potentiation of hepatic encephalopathy. Conivaptan – an antagonist of both V 1A and V 2 vasopressin ...
The choice between the drugs is to a large degree determined by the characteristics of the patient being prescribed for, the drugs' side effects, and cost. Most drugs have other uses; sometimes the presence of other symptoms can warrant the use of one particular antihypertensive. Examples include: Age can affect the choice of medications.
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