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Redox therapy is an experimental therapy [1] [2] that aims to effect an outcome by modifying the levels of pro-oxidant and antioxidant agents in cells. [3] The term "redox" is a contraction of "reduction-oxidation". For cancer patients, the therapy is predicated on the idea that the redox state of cells may have an effect on cancer development. [4]
In terms of cancer prevention, a 2019 study found that participants with the highest intake of lutein and zeaxanthin had the lowest risk of colorectal cancer. Vitamin A Salmon is rich in vitamin A ...
NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation, according to preliminary research. [6] In vitro, NRF2 binds to antioxidant response elements (AREs) in the promoter regions of genes encoding cytoprotective proteins. [7]
Lipophilic antioxidants [3] and iron chelators [1] can prevent ferroptotic cell death. Researchers have identified roles in which oxytosis/ferroptosis can contribute to the medical field, such as the development of cancer therapies. [4] Ferroptosis activation plays a regulatory role on growth of tumor cells in the human body.
[3] [4] [5] By non-antioxidant mechanisms still undefined, polyphenols may affect mechanisms of cardiovascular disease or cancer. [6] The increase in antioxidant capacity of blood seen after the consumption of polyphenol-rich (ORAC-rich) foods is not caused directly by the polyphenols, but most likely results from increased uric acid levels ...
Metabolic reprogramming in cancer is largely due to the oncogenic activation of signal transduction pathways and transcription factors. Although less well understood, epigenetic mechanisms also contribute to the regulation of metabolic gene expression in cancer. Reciprocally, accumulating evidence suggests that metabolic alterations may affect ...
The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two ...
Beets are a rich source of antioxidants. Antioxidants neutralize free radicals. Both are molecules that circulate in the body. Think of antioxidants as the good guys and free radicals as the bad guys.