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The heart derives from embryonic mesodermal germ layer cells that differentiate after gastrulation into mesothelium, endothelium, and myocardium.Heart induction occurs in the anterior mesoderm during gastrulation through interactions with adjacent endoderm (both extra-embryonic and definitive) mediated primarily by endogenous inhibitors of WNT signaling such as DKK1.
The direction of asymmetry is established much earlier during embryonic development, possibly by the clockwise rotation of cilia, and leads to sided expression of Pitx2. Looping also depends on heart specific proteins activated by Nkx2.5 such as Hand1 , Hand2 , and Xin.
The primitive ventricle or embryonic ventricle of the developing heart, together with the bulbus cordis that lies in front of it, gives rise to the left and right ventricles. The primitive ventricle provides the trabeculated parts of the walls, and the bulbus cordis the smooth parts.
The primitive atrium is a stage in the embryonic development of the human heart.It grows rapidly and partially encircles the bulbus cordis; the groove against which the bulbus cordis lies is the first indication of a division into right and left atria.
Human embryonic development covers the first eight weeks of development, which have 23 stages, called Carnegie stages. At the beginning of the ninth week, the embryo is termed a fetus (spelled "foetus" in British English). In comparison to the embryo, the fetus has more recognizable external features and a more complete set of developing organs.
The tubular heart or primitive heart tube is the earliest stage of heart development. [1] The heart is the first organ to develop during human embryonic development. [2]From the inflow to the outflow, the tubular heart consists of sinus venosus, primitive atrium, the primitive ventricle, the bulbus cordis, and truncus arteriosus. [3]
Endocardial cushions, or atrioventricular cushions, refer to a subset of cells in the development of the heart that play a vital role in the proper formation of the heart septa. They develop on the atrioventricular canal [2] and conotruncal region of the bulbus cordis. [3] During heart development, the heart starts out as a tube. As heart ...
The truncus arteriosus is a structure that is present during embryonic development. [clarification needed] It is an arterial trunk that originates from both ventricles of the heart that later divides into the aorta and the pulmonary trunk. [1]