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HIV/AIDS explained in a simple way HIV replication cycle. After the virus enters the body, there is a period of rapid viral replication, leading to an abundance of virus in the peripheral blood. During primary infection, the level of HIV may reach several million virus particles per milliliter of blood. [101]
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Since the use of triple therapy, HIV transmission rates from mother to child for those on triple drug ART has decreased to around 1.9%, while the transmission rates among all pregnant women treated for HIV in any form has dropped to 9.2%, both of which are significant decreases from the initial 27% vertical transmission. [2]
Contrary to popular belief, the primary mode of HIV transmission in the region is heterosexual sex. [1] The number of new HIV infections among women became and continues to be higher than those among men. [1] Currently, the Caribbean is the only area outside of Sub-Saharan Africa where women and girls outnumber men and boys living with HIV. [2]
HIV is spread primarily by unprotected sex (including anal, and oral sex), contaminated blood transfusions, and hypodermic needles. It can also be spread from mother to child during pregnancy, delivery, or breastfeeding. [6] Some bodily fluids, such as saliva and tears, do not transmit HIV. [7]
HIV-1 is more virulent and more infective than HIV-2, [20] and is the cause of the majority of HIV infections globally. The lower infectivity of HIV-2, compared to HIV-1, implies that fewer of those exposed to HIV-2 will be infected per exposure. Due to its relatively poor capacity for transmission, HIV-2 is largely confined to West Africa. [21]
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