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  2. Pacemaker current - Wikipedia

    en.wikipedia.org/wiki/Pacemaker_current

    The pacemaker current (I f, or I Kf, also called funny current) is an electric current in the heart that flows through the HCN channel or pacemaker channel. Such channels are important parts of the electrical conduction system of the heart and form a component of the natural pacemaker .

  3. Pacemaker potential - Wikipedia

    en.wikipedia.org/wiki/Pacemaker_potential

    Bio-pacemakers are the outcome of a rapidly emerging field of research into a replacement for the electronic pacemaker. The bio-pacemaker turns quiescent myocardial cells (e.g. atrial cells) into pacemaker cells. This is achieved by making the cells express a gene which creates a pacemaker current. [10]

  4. Cardiac pacemaker - Wikipedia

    en.wikipedia.org/wiki/Cardiac_pacemaker

    However, in pacemaker cells, this potassium permeability (efflux) decreases as time goes on, causing a slow depolarization. In addition, there is a slow, continuous inward flow of sodium, called the "funny" or pacemaker current. These two relative ion concentration changes slowly depolarize (make more positive) the inside membrane potential ...

  5. HCN channel - Wikipedia

    en.wikipedia.org/wiki/HCN_channel

    HCN4 is the main isoform expressed in the sinoatrial node, but low levels of HCN1 and HCN2 have also been reported.The current through HCN channels, called the pacemaker current (I f), plays a key role in the generation and modulation of cardiac rhythmicity, [13] as they are responsible for the spontaneous depolarization in pacemaker action potentials in the heart.

  6. Cardiac action potential - Wikipedia

    en.wikipedia.org/wiki/Cardiac_action_potential

    Hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) are located mainly in pacemaker cells, these channels become active at very negative membrane potentials and allow for the passage of both Na + and K + into the cell (which is a movement known as a funny current, I f). These poorly selective, cation (positively charged ...

  7. Arnold Schwarzenegger just got a pacemaker. Here's what to ...

    www.aol.com/lifestyle/arnold-schwarzenegger-just...

    Pacemakers are also sometimes used to regulate the heartbeats in people with congenital heart disease, a group of conditions that affect about 1% of people born in the U.S., according to the ...

  8. Dario DiFrancesco - Wikipedia

    en.wikipedia.org/wiki/Dario_DiFrancesco

    Dario DiFrancesco (born 10 February 1948) [1] is a Professor Emeritus at the University of Milano.In 1979, he and collaborators discovered the so-called "funny" (or "pacemaker") current in cardiac pacemaker cells, [2] a new mechanism involved in the generation of cardiac spontaneous activity and autonomic regulation of heart rate. [3]

  9. Arnold Schwarzenegger Shares 1st Photos With Pacemaker After ...

    www.aol.com/entertainment/arnold-schwarzenegger...

    In the snap, Schwarzenegger, 76, can be seen relaxing in a chair, wearing his “pacemaker” — a clock with a “high voltage” sign attached — as he looks at the camera. “Thank you!