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Schematic of the HPA axis (CRH, corticotropin-releasing hormone; ACTH, adrenocorticotropic hormone) Hypothalamus, pituitary gland, and adrenal cortex The hypothalamic–pituitary–adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three components: the hypothalamus (a part of the brain located below the thalamus), the pituitary gland (a ...
Stress can cause depression and depression-like symptoms through monoaminergic changes in several key brain regions as well as suppression in hippocampal neurogenesis. [118] This leads to alteration in emotion and cognition related brain regions as well as HPA axis dysfunction.
Key mechanisms implicated in PSD include glutamate toxicity, HPA axis dysfunction, abnormal neurotrophic response, decreased monoamine levels. [3] Collectively, these mechanisms are most pronounced in the frontal lobes, hippocampus, limbic system, and basal ganglia. [3] Strokes affecting these regions of the brain are thus more likely to cause PSD.
Glucocorticoid deficiency can also be acquired after birth due to damage or dysfunction of the hypothalamus-pituitary-adrenal axis (HPA axis), which regulates cortisol production. [4] Common causes of acquired glucocorticoid deficiency include autoimmune conditions affecting the HPA axis (such as autoimmune adrenalitis) and infections, such as ...
Changes to the HPA Axis Due to Childhood Trauma Hypothalamic-pituatary-adrenal (HPA) axis is essential component of the neuroendocrine system that regulates stress response. Persistent dysregulation of the stress response pathway resulting from childhood trauma causes alterations in the (HPA).
An overview of how cortisone reductase is driven by NADH production by hexose-6-phosphate and how it affects the HPA Axis in a healthy body. Cortisone Reductase Deficiency effects on HPA and body in presence of deficient H6PD. In a healthy body, blood cortisone and cortisol levels are roughly equimolar. [7]
Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. [1]
They can be classified as a hypothalamic–pituitary axis (HP axis) of which the adrenal (HPA Tooltip hypothalamic–pituitary–adrenal axis), gonadal (HPG Tooltip hypothalamic–pituitary–gonadal axis), thyroid (HPT Tooltip hypothalamic–pituitary–thyroid axis), somatotropic (HPS Tooltip hypothalamic–pituitary–somatotropic axis), and ...