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NICE publishes guidelines in four areas: the use of health technologies within England's National Health Service (NHS) (such as the use of new and existing medicines, treatments and procedures) clinical practice (guidance on the appropriate treatment and care of people with specific diseases and conditions)
Several approved drugs are being investigated as repurposed agents in the treatment of osteoarthritis such as liraglutide (anti-diabetic and anti-obesity drug: NCT02905864), Metformin (anti-diabetic drug: NCT04767841, NCT05034029), Zoledronic acid (anti-osteoporotic drug: NCT04303026), etc. [4] Paroxetine has been deemed to have DMOAD activity ...
Osteoarthritis is the most common form of arthritis, affecting about 237 million people or 3.3% of the world's population as of 2015. [4] [12] It becomes more common as people age. [1] Among those over 60 years old, about 10% of males and 18% of females are affected. [2] Osteoarthritis is the cause of about 2% of years lived with disability. [12]
The cells targeted for the treatment of osteoarthritis are chondrocytes, synoviocytes, and their progenitors. Since the joint capsule is relatively well contained, intra-articular injections are highly successful at delivering the therapeutic gene therapy locally to the target cell types. Treatment of osteoarthritis may be successful via:
The primary surgical treatment option of arthritis is joint replacement surgery known as arthroplasty. [92] Common joints that are replaced due to arthritis include the shoulder, hip, and knee. [92] Arthroscopic surgery for osteoarthritis of the knee provides no additional benefit to patients when compared to optimized physical and medical ...
Post-traumatic osteoarthritis is the most common variation of post-traumatic arthritis. [3] Between 20 and 50% [ 4 ] of all osteoarthritis cases are preceded by post-traumatic arthritis. Patients having post-traumatic osteoarthritis are usually younger than osteoarthritis patients without any previous physical injuries.