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Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be compliant with their anticonvulsant drug regimen. Medications that lower seizure threshold include the antidepressant and nicotinic antagonist bupropion, the atypical opioid analgesics tramadol and ...
Tapentadol has been demonstrated to reduce the seizure threshold in patients. Tapentadol should be used cautiously in patients with a history of seizures, and in patients who are also taking one or more other drugs which have also been demonstrated to reduce the seizure threshold.
Therefore, almost all new epilepsy drugs are initially approved only as adjunctive (add-on) therapies. Patients whose epilepsy is uncontrolled by their medication (i.e., it is refractory to treatment) are selected to see if supplementing the medication with the new drug leads to an improvement in seizure control.
Bupropion lowers the seizure threshold, and therefore can potentially interact with other medications that also lower it, such as antipsychotics, tricyclic antidepressants, theophylline, and systemic corticosteroids. [10] The prescribing information recommends minimizing the use of alcohol, since in rare cases bupropion reduces alcohol ...
Cholinergic blocking drugs are a group of drugs that block the action of acetylcholine (ACh), ... May reduce seizure threshold. [27] Muscle relaxants for surgery.
Wellbutrin can also interact with some medications, including other antidepressants, clopidogrel and medications that reduce the seizure threshold. To reduce your risk of drug interactions, make ...