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The megakaryocyte develops through the following lineage: CFU-Meg (hematopoietic stem cell/hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte. Megakaryocytes are derived from hematopoietic stem cell precursor cells in the bone marrow. They are produced primarily by the liver, kidney, spleen, and bone marrow.
During thrombopoiesis, the promegakaryocyte matures into the form of a megakaryocyte. From the megakaryocyte, platelets are formed. [1] The megakaryoblast is the beginning of the thrombocytic series or platelet forming series. Megakaryoblasts typically have a large oval-shaped nucleus or a nucleus that is lobed with many nuclei. [2]
Two different models of the process of creation existed in ancient Israel. [15] In the "logos" (speech) model, God speaks and shapes unresisting dormant matter into effective existence and order (Psalm 33: "By the word of YHWH the heavens were made, and by the breath of his mouth all their hosts; he gathers up the waters like a mound, stores the Deep in vaults"); in the second, or "agon ...
Promegakaryocyte. A promegakaryocyte is a precursor cell for a megakaryocyte, the development of which proceeds as follows: [1]. CFU-Meg (hematopoietic stem cell/hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte
In order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, CFU-GEMM. This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production of megakaryocytes. [1] [2] [3] Some sources prefer the term "CFU-Mega". [4]
Langhans giant cells are named for the pathologist who discovered them, Theodor Langhans. Like many of the other kinds of giant cell formations, epithelioid macrophages fuse together and form a multinucleated giant cell. The nuclei form a circle or semicircle similar to the shape of a horseshoe away from the center of the cell.
Rock and dust samples retrieved by NASA from the asteroid Bennu exhibit some of the chemical building blocks of life, according to research that provides some of the best evidence to date that ...
Replica of the ark of the covenant, with the "mercy seat" (kaporet) acting as lid.According to the Hebrew Bible, the kaporet (Hebrew: כַּפֹּרֶת kapōreṯ) or mercy seat was the gold lid placed on the Ark of the Covenant, with two cherubim at the ends to cover and create the space in which Yahweh appeared and dwelled.