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While Calhoun was working at the National Institute of Mental Health (NIMH) in 1954, he began numerous experiments with rats and mice. During his first tests, he placed around 32 to 56 rats in a 10-by-14-foot (3.0 m × 4.3 m) cage in a barn in Montgomery County. He separated the space into four rooms.
The cages are constructed and designed in a specific way to ensure an absolute microparticle free inner environment. This generally includes a cage bottom, a cage top (with a food hopper and water bottle holder incorporated) and a filter lid. It is also designed to allow maximum comfort of the animal and to provide a secure, chew proof environment.
Mice are naturally cautious of rats, who may kill and consume them. This behaviour is known as muricide (cf. Muricidal test). [16] The mouse cage should be cleaned every week to prevent odour and disinfected only if a mouse has been unwell to prevent infection and disease. In the wild, mice are able to co-exist with other small rodent species. [17]
Group CC was isolated in laboratory cages when they were weaned at 22 days of age, and lived there until the experiment ended at 80 days of age; Group PP was housed in Rat Park for the same period; Group CP was moved from laboratory cages to Rat Park at 65 days of age; and Group PC was moved out of Rat Park and into cages at 65 days of age.
Skinner box. An operant conditioning chamber (also known as a Skinner box) is a laboratory apparatus used to study animal behavior.The operant conditioning chamber was created by B. F. Skinner while he was a graduate student at Harvard University.
Male mice tend to have a stronger odor than the females. However, mice are careful groomers and as pets they never need bathing. Well looked-after mice can make ideal pets. Some common mouse care products are: Cage – Usually a hamster or gerbil cage, but a variety of special mouse cages are now available. Most should have a secure door.