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The AP-1 transcription factor also has been shown to be involved in breast cancer cell growth through multiple mechanisms, including regulation of cyclin D1, E2F factors and their target genes. c-Jun, which is one of the AP-1 subunits, regulates the growth of breast cancer cells.
3725 16476 Ensembl ENSG00000177606 ENSMUSG00000052684 UniProt P05412 P05627 RefSeq (mRNA) NM_002228 NM_010591 RefSeq (protein) NP_002219 NP_034721 Location (UCSC) Chr 1: 58.78 – 58.78 Mb Chr 4: 94.94 – 94.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos ...
The AP-1 binding site, also known as the AP-1 promoter site, is a DNA sequence to which AP-1 transcription factors are able to bind. [1] The AP-1 binding site, in humans, has a nucleotide sequence of ATGAGTCAT, where A corresponds to adenine, T corresponds to thymine, G corresponds to guanine, and C corresponds to cytosine.
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. [5] [6] [7]Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors.
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1174 11769 Ensembl ENSG00000106367 ENSMUSG00000004849 UniProt P61966 P61967 RefSeq (mRNA) NM_057089 NM_001283 NM_007457 RefSeq (protein) NP_001274 NP_031483 Location (UCSC) Chr 7: 101.15 – 101.16 Mb Chr 5: 137.06 – 137.07 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. Function The protein ...
The Federal Reserve’s report on industrial production also found that factory output slipped 0.1% in January, largely due to a 5.2% drop in the making of motor vehicles and parts.
The agency has been a target of conservatives since President Barack Obama pushed to include it in the 2010 financial reform legislation that followed the 2007-2008 financial crisis.