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Cyanocobalamin is a form of vitamin B. 12 used to treat and prevent vitamin B. 12 deficiency except in the presence of cyanide toxicity. [7][8][2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer.
The structure of vitamin B 12 was the first low-molecular weight natural product determined by x-ray analysis rather than by chemical degradation. Thus, while the structure of this novel type of complex biomolecule was established, its chemistry remained essentially unknown; exploration of this chemistry became one of the tasks of the vitamin's chemical synthesis.
Cyanocobalamin is a manufactured form of B 12. Bacterial fermentation creates AdoB 12 and MeB 12, which are converted to cyanocobalamin by the addition of potassium cyanide in the presence of sodium nitrite and heat. Once consumed, cyanocobalamin is converted to the biologically active AdoB 12 and MeB 12. The two bioactive forms of vitamin B
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6% (< 60 years old), 20% (> 60 years old) [4] Vitamin B12 deficiency, also known as cobalamin deficiency, is the medical condition in which the blood and tissue have a lower than normal level of vitamin B 12. [5] Symptoms can vary from none to severe. [1] Mild deficiency may have few or absent symptoms. [1]
No overdosage or toxicity has been reported with this drug. [2] Hydroxocobalamin is the natural form of vitamin B 12 and a member of the cobalamin family of compounds. [6][7] It is found in both raw and cooked beef, together with other cobalamins. [8] Hydroxocobalamin, or another form of vitamin B 12, are required for the body to make DNA.
Methylcobalamin (mecobalamin, MeCbl, or MeB 12) is a cobalamin, a form of vitamin B 12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. [1] Methylcobalamin features an octahedral cobalt (III) centre and can be obtained as bright red crystals. [2] From the perspective of coordination ...