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Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disorder that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood. [1] It is divided in two main categories: T-cell LGL leukemia (T-LGLL) and natural-killer (NK)-cell LGL leukemia (NK-LGLL).
The center's director, Thomas P. Loughran Jr., discovered and is considered a leading expert in large granular lymphocytic (LGL) leukemia. He succeeded Michael J. Weber, who stepped down in 2013 after twelve years of service. [10] UVA Cancer Center is funded as a partner in the federal Cancer Moonshot. [11]
JTCC is part of Hackensack University Medical Center. HUMC and part of the Hackensack Meridian Health network, which includes Joseph M. Sanzari Children's Hospital, the Cancer Center, a branch of The Betty Torricelli Institute for Breast Care, Ocean Medical Center, Pascack Valley Medical Center, and the Riverview Medical Center. [11] [12] [13]
Treatment may involve some combination of chemotherapy, radiation therapy, targeted therapy, and bone marrow transplant, with supportive and palliative care provided as needed. [3] [6] Certain types of leukemia may be managed with watchful waiting. [3] The success of treatment depends on the type of leukemia and the age of the person.
Aggressive NK-cell leukemia is a disease with an aggressive, systemic proliferation of natural killer cells (NK cells) and a rapidly declining clinical course. [ 1 ] [ 2 ] [ 3 ] It is also called aggressive NK-cell lymphoma .
St. Jude Children's Research Hospital is a pediatric treatment and research hospital headquartered in Memphis, Tennessee.Founded by entertainer Danny Thomas in 1962, it is a 501(c)(3) designated nonprofit medical corporation which focuses on children's catastrophic diseases, particularly leukemia and other cancers. [1]