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  2. Relationship between telomeres and longevity - Wikipedia

    en.wikipedia.org/wiki/Relationship_between...

    Extending telomeres can allow cells to divide more and increase the risk of uncontrolled cell growth and cancer development. [24] A study conducted by Johns Hopkins University challenged the idea that long telomeres prevent aging. Rather than protecting cells from aging, long telomeres help cells with age-related mutations last longer. [13]

  3. Shelterin - Wikipedia

    en.wikipedia.org/wiki/Shelterin

    Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate telomerase activity. In mammals and other vertebrates, telomeric DNA consists of repeating double-stranded 5'-TTAGGG-3' (G-strand) sequences (2-15 kilobases in humans) along with the 3'-AATCCC-5' (C-strand) complement, ending with a 50-400 ...

  4. Telomeres in the cell cycle - Wikipedia

    en.wikipedia.org/wiki/Telomeres_in_the_cell_cycle

    Almost all cancer cells have shortened telomeres. [20] This may seem counter-intuitive, as short telomeres should activate the ATR/ATM DNA damage checkpoint and thereby prevent division. Resolving the question of why cancer cells have short telomeres led to the development of a two-stage model for how cancer cells subvert telomeric regulation ...

  5. Alternative Lengthening of Telomeres - Wikipedia

    en.wikipedia.org/wiki/Alternative_lengthening_of...

    Alternative Lengthening of Telomeres (also known as "ALT") is a telomerase-independent mechanism by which cancer cells avoid the degradation of telomeres.. At each end of the chromosomes of most eukaryotic cells, there is a telomere: a region of repetitive nucleotide sequences which protects the end of the chromosome from deterioration or from fusion with neighboring chromosomes.

  6. Biological immortality - Wikipedia

    en.wikipedia.org/wiki/Biological_immortality

    The term "immortalization" was first applied to cancer cells that expressed the telomere-lengthening enzyme telomerase, and thereby avoided apoptosis—i.e. cell death caused by intracellular mechanisms. Among the most commonly used cell lines are HeLa and Jurkat, both of which are immortalized cancer cell lines. [4]

  7. Telomerase - Wikipedia

    en.wikipedia.org/wiki/Telomerase

    The existence of a compensatory mechanism for telomere shortening was first found by Soviet biologist Alexey Olovnikov in 1973, [4] who also suggested the telomere hypothesis of aging and the telomere's connections to cancer and perhaps some neurodegenerative diseases. [5]

  8. A busy longevity clinic owner is 33 but says her biological ...

    www.aol.com/busy-longevity-clinic-owner-33...

    Barnes-Lentz works from 7:30 a.m. to 5 p.m. most days, running her longevity business, podcast, and social media accounts, including her Instagram account, which has 383,000 followers.

  9. Epitalon - Wikipedia

    en.wikipedia.org/wiki/Epitalon

    Elongation of telomeres by epitalon was sufficient to surpass the Hayflick limit in a cell culture of human fetal fibroblast cells, extending their proliferative potential from termination at the 34th passage in the control cell population to beyond the 44th passage in the treated cell population, while increasing the lengths of their telomeres ...