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Mallory–Weiss syndrome is a condition where high intra-abdominal pressures causes laceration and bleeding of the mucosa called Mallory-Weiss tears. [1] Additionally, Mallory–Weiss syndrome is one of the most common causes of acute upper gastrointestinal bleeding , counting of around 1-15% of all cases in adults and less than 5% in children.
In 1929, Mallory and Soma Weiss, a physician at Harvard, reported on 15 cases of severe, painless hemorrhage caused by a tear in the mucosa of the esophagus or gastroesophageal junction preceded by vomiting in alcoholic patients. [3] They reported a further six cases in 1932. [4] This syndrome has become known as Mallory–Weiss syndrome.
Esophageal rupture, also known as Boerhaave syndrome, is a rupture of the esophageal wall. Iatrogenic causes account for approximately 56% of esophageal perforations, usually due to medical instrumentation such as an endoscopy or paraesophageal surgery. [1] The 10% of esophageal perforations caused specifically by vomiting are termed Boerhaave ...
Recurrent or refractory bleeding may lead to need for surgery, although this has become uncommon as a result of improved endoscopic and medical treatment. Upper gastrointestinal bleeding affects around 50 to 150 people per 100,000 a year. It represents over 50% of cases of gastrointestinal bleeding. [2]
Esophageal inflammation and erosive disease are the next most common causes. [3] In those with liver cirrhosis, 50–60% of bleeding is due to esophageal varices. [3] Approximately half of those with peptic ulcers have an H. pylori infection. [3] Other causes include Mallory-Weiss tears, cancer, and angiodysplasia. [2]
An endoclip is a metallic mechanical device used in endoscopy in order to close two mucosal surfaces without the need for surgery and suturing. Its function is similar to a suture in gross surgical applications, as it is used to join together two disjointed surfaces, but, can be applied through the channel of an endoscope under direct visualization
A judge told the parents of 27-year-old Ellen Greenberg, a Philadelphia teacher found dead with 20 stab wounds in 2011, that the city's declaration of suicide was "puzzling."
Mallory–Weiss syndrome: bleeding tears in the esophagal mucosa, usually caused by prolonged and vigorous retching. [4] Vomiting of ingested blood after bleeding in the mouth, nose, or throat. [4] Tumors of the stomach or esophagus. [4] Irritation or erosion of the lining of the esophagus or stomach. Radiation poisoning. Viral hemorrhagic fevers.