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Ball-and-stick model of a glucose molecule. Blood sugar regulation is the process by which the levels of blood sugar, the common name for glucose dissolved in blood plasma, are maintained by the body within a narrow range. The regulation of glucose levels through Homeostasis. This tight regulation is referred to as glucose homeostasis.
The glucose cycle can occur in liver cells due to a liver specific enzyme glucose-6-phosphatase, which catalyse the dephosphorylation of glucose 6-phosphate back to glucose. Glucose-6-phosphate is the product of glycogenolysis or gluconeogenesis, where the goal is to increase free glucose in the blood due body being in catabolic state. Other ...
Glycolysis is the metabolic pathway that converts glucose (C 6 H 12 O 6) into pyruvate and, in most organisms, occurs in the liquid part of cells (the cytosol). The free energy released in this process is used to form the high-energy molecules adenosine triphosphate (ATP) and reduced nicotinamide adenine dinucleotide (NADH). [1]
In the liver, muscles, and the kidney, this process occurs to provide glucose when necessary. [12] A single glucose molecule is cleaved from a branch of glycogen, and is transformed into glucose-1-phosphate during this process. [1] This molecule can then be converted to glucose-6-phosphate, an intermediate in the glycolysis pathway. [1]
Figure 2: Regulation of metabolic pathways maintains blood glucose concentration at approximately 5 mM in humans. Blood glucose levels are maintained at a steady state concentration by balancing the rate of entry of glucose into the blood stream (i.e. by ingestion or released from cells) and the rate of glucose uptake by body tissues. [1]
The cannabinoid receptor type 1, located at the presynaptic neuron, is a receptor that can stop stressful neurotransmitter release to the postsynaptic neuron; it is activated by endocannabinoids such as anandamide (N-arachidonoylethanolamide) and 2-arachidonoylglycerol via a retrograde signaling process in which these compounds are synthesized ...
The process of the regulation of blood glucose (also known as glucose homeostasis) also exhibits oscillatory behavior. On a pathological basis, this topic is crucial to understanding certain disorders in the body such as diabetes , hyperglycemia and hypoglycemia .
Glucose homeostasis, when operating normally, restores the blood sugar level to a narrow range of about 4.4 to 6.1 mmol/L (79 to 110 mg/dL) (as measured by a fasting blood glucose test). [10] The global mean fasting plasma blood glucose level in humans is about 5.5 mmol/L (100 mg/dL); [11] [12] however, this level fluctuates throughout the day ...