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Potassium channel blockers exhibit reverse use-dependent prolongation of the action potential duration. Reverse use dependence is the effect where the efficacy of the drug is reduced after repeated use of the tissue. [11] This contrasts with (ordinary) use dependence, where the efficacy of the drug is increased after repeated use of the tissue.
Pages in category "Potassium channel blockers" The following 66 pages are in this category, out of 66 total. This list may not reflect recent changes. ...
Class of medications that are competitive antagonists that block the receptor sites for the endogenous catecholamines epinephrine (adrenaline) and norepinephrine (noradrenaline) on adrenergic beta receptors, of the sympathetic nervous system.
Class I agents interfere with the sodium (Na +) channel. Class II agents are anti-sympathetic nervous system agents. Most agents in this class are beta blockers. Class III agents affect potassium (K +) efflux. Class IV agents affect calcium channels and the AV node. Class V agents work by other or unknown mechanisms.
Example of voltage-dependent potassium ion channel in relation to changing ion concentrations . To comprehend the mechanism of channel blockers, it is critical to understand the composition of ion channels. Their main function is to contribute to the resting membrane potential of a cell via the flow of ions through a cell membrane.
The following table contains a comparison of the major classes of potassium channels with representative examples (for a complete list of channels within each class, see the respective class pages). For more examples of pharmacological modulators of potassium channels, see potassium channel blocker and potassium channel opener.
Potassium channel blockers (1 C, 66 P) S. Sodium channel blockers (1 C, 77 P) Pages in category "Antiarrhythmic agents" The following 59 pages are in this category ...
A channel opener, also known as a channel activator, is a type of drug which facilitates ion flow through ion channels. They include the following: Potassium channel openers; Calcium channel openers; Sodium channel openers; Chloride channel openers